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While glutathione is certainly an important physiological antioxidant of Hg, the glutathione-Hg conjugates might also contribute to intracellular retention of Hg since these conjugates may not be transported easily out of the proximal tubule cells 23,24

Their chemistry is directly connected through the NADPH pathway, so good NAD+ status helps recycle glutathione, and strong glutathione levels protect NAD+

The peptide does not interact with hormonal pathways, making it one of the few compounds where sex-based dose adjustment is unnecessary

The model was first fitted to the training concentrations (37.5 and 25 M doxorubicin), and then used to simulate the test concentrations (50, 12.5 and 10 M doxorubicin) as a means of blind validation, showing good accordance between the experimental and in silico outputs for all concentrations of doxorubicin